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Pirfenidone 400 mg (Pirfenex)
Home Pirfenidone Pirfenidone 400 mg (Pirfenex)
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Pirfenidone 400 mg (Pirfenex)

$120.00 – $500.00

Pirfenidone 400 mg (Pirfenex) is used to treat idiopathic pulmonary fibrosis (IPF). It works by reducing inflammation and fibrosis in the lungs, improving lung function. While generally safe, it may cause side effects such as nausea, fatigue, and liver enzyme changes. Always follow your doctor’s guidance for proper use.

Thumbnail Tablet PriceQuantity
Pirfenidone 400 mg (Pirfenex) - 100 Tablet/s 100 Tablet/s $120.00
Pirfenidone 400 mg (Pirfenex) - 200 Tablet/s 200 Tablet/s $230.00
Pirfenidone 400 mg (Pirfenex) - 300 Tablet/s 300 Tablet/s $335.00
Pirfenidone 400 mg (Pirfenex) - 400 Tablet/s 400 Tablet/s $430.00
Pirfenidone 400 mg (Pirfenex) - 500 Tablet/s 500 Tablet/s $500.00
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Description

What is Pirfenidone 400 mg (Pirfenex)?

Pirfenidone 400 mg, marketed under the brand name Pirfenex, is an antifibrotic medication used to treat idiopathic pulmonary fibrosis (IPF). IPF is a chronic lung disease that causes progressive scarring of lung tissue, making it difficult to breathe. Pirfenidone helps to slow the progression of fibrosis and preserve lung function, offering patients an improved quality of life.

Pirfenidone is an oral medication, and it works by targeting the pathways that lead to the formation of fibrous tissue (scar tissue) in the lungs. It is known for its anti-inflammatory, antioxidant, and antifibrotic properties, which help reduce the buildup of scar tissue and prevent further lung damage.

How Does Pirfenidone 400 mg (Pirfenex) Work?

Pirfenidone works by modulating the body’s natural response to injury and inflammation, which are key contributors to fibrosis. Here’s how it works:

  1. Inhibition of Fibrosis Formation:
    Fibrosis occurs when excess collagen is produced, leading to scarring in lung tissue. Pirfenidone reduces the activity of fibroblasts, the cells responsible for collagen production, helping to prevent further scarring in the lungs.
  2. Anti-inflammatory Effects:
    Chronic inflammation is one of the primary factors in the development of fibrosis. Pirfenidone has anti-inflammatory properties that help reduce the inflammatory response in the lungs, limiting further tissue damage.
  3. Antioxidant Properties:
    Oxidative stress, which results from an imbalance of free radicals, contributes to the progression of fibrosis. Pirfenidone has antioxidant effects, neutralizing free radicals and reducing oxidative damage to lung cells.

By targeting these mechanisms, Pirfenidone helps slow the progression of IPF and preserve lung function, which is critical for improving patients’ overall health and well-being.

Benefits of Pirfenidone 400 mg (Pirfenex)

  1. Slows the Progression of Idiopathic Pulmonary Fibrosis (IPF):
    The primary benefit of Pirfenidone is its ability to slow down the progression of IPF. By reducing the formation of scar tissue in the lungs, Pirfenidone helps maintain lung function for a longer period, improving the quality of life for patients.
  2. Improves Exercise Capacity:
    Clinical studies have shown that Pirfenidone can improve exercise capacity in patients with IPF. This is particularly beneficial for individuals who experience difficulty breathing and fatigue due to their condition. By improving lung function, patients may find it easier to perform everyday activities.
  3. Reduces the Risk of Acute Exacerbations:
    Acute exacerbations of IPF can cause sudden and severe worsening of symptoms. Pirfenidone has been shown to reduce the frequency and severity of these exacerbations, which can help prevent hospitalizations and improve long-term outcomes.
  4. Improves Overall Quality of Life:
    By slowing disease progression and improving lung function, Pirfenidone can enhance the quality of life for patients. This medication can help individuals with IPF live more active lives and manage their symptoms more effectively.

How to Take Pirfenidone 400 mg (Pirfenex)

  • Dosage:
    The typical starting dose of Pirfenidone is 400 mg taken three times a day, for a total daily dose of 1200 mg. Your doctor may gradually increase or decrease the dose based on your response to the medication and any side effects you experience.
  • Administration:
    Pirfenidone should be taken with food to improve absorption and reduce the risk of stomach upset. Swallow the tablets whole with a glass of water. Do not crush, chew, or break the tablets.
  • Missed Dose:
    If you miss a dose, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once to make up for a missed dose.
  • Consistency:
    Take Pirfenidone at the same time each day to help you remember. Do not stop taking the medication without consulting your doctor, as abrupt discontinuation can worsen your condition.

Who Makes Pirfenidone 400 mg (Pirfenex)?

Pirfenidone 400 mg (Pirfenex) is manufactured by Cipla, a global pharmaceutical company that produces a wide range of medications, including those for respiratory conditions. Cipla has played a significant role in making Pirfenidone available to patients with idiopathic pulmonary fibrosis, helping to improve their lung health and quality of life.

Is Pirfenidone 400 mg (Pirfenex) Safe for Humans?

Pirfenidone 400 mg is generally safe for most people when taken as prescribed. However, like all medications, it comes with potential risks. It is important to follow your doctor’s instructions carefully and report any side effects promptly.

Pirfenidone should be used with caution in individuals with liver problems, as it can affect liver function. Liver function tests should be performed regularly during treatment to monitor for any abnormalities. It is also not recommended for use during pregnancy or breastfeeding unless the benefits outweigh the risks. Always inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Side Effects of Pirfenidone 400 mg (Pirfenex)

While Pirfenidone is effective in treating IPF, it can cause side effects in some individuals. Common side effects include:

  • Nausea and vomiting
  • Fatigue
  • Loss of appetite
  • Diarrhea
  • Rash or skin reactions (e.g., redness, itching)
  • Headache

Serious side effects, although rare, may include:

  • Liver toxicity: Elevated liver enzymes may indicate liver damage, requiring discontinuation of the medication.
  • Severe skin reactions: Some individuals may experience severe rashes or blistering, which requires immediate medical attention.
  • Breathing difficulties: If you experience shortness of breath or a persistent cough, contact your doctor immediately.

If you experience any severe side effects, seek medical help promptly.

Disclaimer

This content is for informational purposes only and should not be used as a substitute for professional medical advice. Always consult your healthcare provider before starting or discontinuing any medication, including Pirfenidone 400 mg. Follow your doctor’s instructions regarding dosage and usage, and report any side effects or concerns immediately.

Additional information
Tablet

100 Tablet/s, 200 Tablet/s, 300 Tablet/s, 400 Tablet/s, 500 Tablet/s

Active Ingredient (Generic Name)

Pirfenidone

Indication

Idiopathic pulmonary fibrosis

Manufacturer

Cipla Ltd

Packaging

15 Tablets in 1 strip

Strength

400 Mg

Delivery Time

6 To 15 days

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